Below you can find high-scoring Significance sections from research project proposals submitted to the National Institutes of Health (NIH). These make the case for the importance of preserving (typically cryopreserving) a variety of organ and tissue systems, such as hearts, livers, limbs, kidneys, whole reproductive organs, and ovarian and testicular tissue.
The eight sections below were generously provided by Sylvatica Biotech, Inc. They have offered them as an open-access resource for organ and tissue preservation researchers, in the hopes that the information and references will be helpful to new Principal Investigators and others looking to bolster their own arguments in grant applications. We owe many thanks to Drs. Mike Taylor, Sebastian Giwa, Simona Baicu, and Bradley Weegman, as well as the rest of the Sylvatica team, for freely sharing their hard-won knowledge.
Contributions by other research groups would be greatly appreciated! All proprietary information can be redacted, and we would be excited to acknowledge your contribution here and in our Biopreservation Briefings newsletter. We firmly believe that every researcher in this field benefits when their fellow scientists are equipped to make the strongest possible case for the public health importance of their work.
Criteria for inclusion of NIH proposal sections:
- At least two out of three reviewers ranked the proposal's significance as "Exceptional" or "Outstanding" (1 or 2 on the 9-point scale)
- All reviewers ranked the proposal's significance as "Excellent" or better (1, 2, or 3 on the 9-point scale)
- The overall proposal need not have been funded, though most sections below are from proposals that were funded.
Any well-received proposal language would be most welcome, if outcomes were comparable to the criteria used for NIH above!